A gene signature for post-infectious Chronic Fatigue Syndrome (Myalgic Encephalomyelities) may be the key to differential diagnosis in this complex neuroimmune disease (ICD-10 G93.3).
Persistent fatigue after infection is recognized and forms part of a clinically-defined syndrome (chronic fatigue syndrome or CFS). CFS is a highly heterogeneous illness which is characterized by the presence of new-onset persistent or relapsing exhaustion of sufficient severity that it interferes with normal activity. Patients also report impaired short-term memory and concentration sleep abnormalities as is consistent with proinflammatory cytokines, musculoskeletal pain which is also recognized in infectious disorders and post exertional malaise.
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